Research

Published findings, in context.

Each finding is shown with the evidence level at which it was observed. A result in an animal model or in cell culture is not a result in humans.

Topic

All topics Tissue damage models Extracellular matrix Cell signaling Cerebral ischemia models Dermal fibroblasts

Evidence level

All levels In vitro Animal Human, observational Human, controlled Review

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Study type

All types In vitro study Animal study Observational (human)Controlled (human)Systematic review Narrative review Case report

Organism

Publication year

1 publication

Compounds filed under Cerebral ischemia models · Systematic review

ReviewSystematic review
Systematic review of 36 studies (35 preclinical, 1 in humans): mechanism, musculoskeletal endpoints, biotransformation and safety
“Emerging Use of BPC-157 in Orthopaedic Sports Medicine: A Systematic Review.”
Vasireddi N, Hahamyan H, Salata MJ et al.HSS Journal2025PMID 40756949 (opens PubMed in a new tab)DOI 10.1177/15563316251355551 (opens the publisher record in a new tab)
Filed under BPC-157
Model
Systematic review (PubMed, Cochrane, Embase; through June 2024) of studies on mechanism, musculoskeletal outcomes, biotransformation and safety
Of 544 records identified, 36 studies were included (35 preclinical and 1 in humans). The authors synthesize functional, structural and biomechanical measures from preclinical musculoskeletal models, together with GHR expression and inflammatory cytokine levels; the only study in humans was retrospective. No human safety data were found, and the evidence was graded as level IV and V.

For laboratory research use only. Not for human or veterinary use or consumption. Not for diagnostic use. Not evaluated by the U.S. FDA.