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Research

Published findings, in context.

Each finding is shown with the evidence level at which it was observed. A result in an animal model or in cell culture is not a result in humans.

Topic

All topicsTissue damage modelsExtracellular matrixCell signalingCerebral ischemia modelsDermal fibroblasts

Evidence level

All levelsIn vitroAnimalHuman, observationalHuman, controlledReview
More filters (study type, organism, year)

Study type

All typesIn vitro studyAnimal studyObservational (human)Controlled (human)Systematic reviewNarrative reviewCase report
Publication year

6 publications

Compounds filed under Cerebral ischemia models · Animal

  • AnimalAnimal study· Rattus norvegicus

    Rat quadriceps detachment model: defect size, function, muscle histology and nitric oxide markers

    Japjec M, Horvat Pavlov K, Petrovic A et al.Biomedicines2021PMID 34829776 (opens PubMed in a new tab)Title on PubMedDOI 10.3390/biomedicines9111547 (opens the publisher record in a new tab)

    Filed under BPC-157

    Model
    Surgical detachment of the quadriceps muscle in the rat; assessment at days 7, 14, 28 and 42
    Exposure
    BPC-157 vs no-peptide controls
    Comparator
    Controls without peptide

    In a rat model of surgical detachment of the quadriceps muscle, the BPC-157 and control groups were compared on defect size, function, muscle atrophy, inflammatory infiltrate and the orientation of the junction tissue from day 7 to day 42, together with eNOS and COX-2 mRNA, oxidative stress and nitric oxide levels; the direction and size of these differences are not summarized in this profile.

  • AnimalAnimal study· Rattus norvegicus (Wistar)

    Rat hippocampal ischemia/reperfusion model: neuronal damage, behavioral tests and hippocampal gene expression

    Vukojević J, Vrdoljak B, Malekinušić D et al.Brain and Behavior2020PMID 32558293 (opens PubMed in a new tab)Title on PubMedDOI 10.1002/brb3.1726 (opens the publisher record in a new tab)

    Filed under BPC-157

    Model
    Ischemia/reperfusion by bilateral clamping of the common carotid arteries (20 min) in male rats; assessment at 24 and 72 h
    Exposure
    BPC-157 vs saline
    Comparator
    Saline

    In rats subjected to cerebral ischemia/reperfusion, hippocampal expression of Egr1, Akt1, Kras, Src, Foxo, Srf, Vegfr2, Nos3 and Nos1 was higher, and that of Nos2 and Nfkb lower, in the BPC-157 group than in saline controls; Mapk1 was not activated. Early and late hippocampal neuronal damage and performance on memory (Morris water maze), locomotion and coordination tests were also assessed; their direction is not summarized in this profile. Exploratory findings in an animal model.

  • AnimalAnimal study· Rattus norvegicus; HUVEC; chick chorioallantoic membrane

    Rat hindlimb ischemia model, chick chorioallantoic membrane and HUVEC: VEGFR2 expression and Akt–eNOS signaling

    Hsieh MJ, Liu HT, Wang CN et al.Journal of Molecular Medicine (Berlin)2017PMID 27847966 (opens PubMed in a new tab)Title on PubMedDOI 10.1007/s00109-016-1488-y (opens the publisher record in a new tab)

    Filed under BPC-157

    Model
    Rat hindlimb ischemia (laser Doppler, histology); chorioallantoic membrane (CAM) assay; tube formation in HUVEC
    Exposure
    BPC-157 vs no-peptide controls (ischemia model and in vitro systems)
    Comparator
    Controls without peptide; blockade with dynasore (endocytosis inhibitor)

    In HUVEC, VEGFR2 mRNA and protein increased (VEGF-A did not), with internalization of the receptor, time-dependent activation of the VEGFR2–Akt–eNOS pathway and greater tube formation; these effects were suppressed by the endocytosis inhibitor dynasore. Vascular density in the chorioallantoic membrane assay, and blood flow (laser Doppler), vessel counts and vascular VEGFR2 in rats with hindlimb ischemia, were also measured; the direction and size of these in vivo endpoints are not summarized in this profile.

  • AnimalAnimal study· Rattus norvegicus; HUVEC; NIH 3T3 cells

    Rat cutaneous alkali-burn model and HUVEC: burned-skin histology, tissue VEGF and endothelial ERK1/2 signaling

    Huang T, Zhang K, Sun L et al.2015PMID 25995620 (opens PubMed in a new tab)Full record on PubMedDOI 10.2147/DDDT.S82030 (opens the publisher record in a new tab)

    Filed under BPC-157

    Model
    Cutaneous alkali burn in the rat, with histological assessment at day 18; cultured human endothelial cells (HUVEC) and NIH 3T3 fibroblasts
    Exposure
    BPC-157 vs no-peptide control (rat model and cell cultures)
    Comparator
    Model control group without peptide

    In a rat cutaneous alkali-burn model, the BPC-157 and control groups were compared on the size of the burned area, granulation tissue, re-epithelialization, extracellular matrix deposition and tissue VEGF; the direction and size of these endpoints are not summarized in this profile. In HUVEC, greater proliferation, migration and tube formation were described, with regulation of ERK1/2 phosphorylation and of c-Fos, c-Jun and Egr-1 expression; these cell findings refer to HUVEC, not to the NIH 3T3 cells also used. Study by a group independent of the originating group.

  • AnimalAnimal study· Rattus norvegicus; cultured tenocytes

    Rat Achilles transection model and cultured tenocytes: biomechanical, functional and histological endpoints

    Staresinic M, Sebecic B, Patrlj L et al.Journal of Orthopaedic Research2003PMID 14554208 (opens PubMed in a new tab)Title on PubMedDOI 10.1016/S0736-0266(03)00110-4 (opens the publisher record in a new tab)

    Filed under BPC-157

    Model
    Complete Achilles tenotomy in the rat; cultured tenocytes exposed to 4-hydroxynonenal
    Exposure
    BPC-157 vs saline vehicle
    Comparator
    Saline

    After complete Achilles tenotomy in rats, the BPC-157 and saline groups were compared on biomechanical measures (load to failure, Young's modulus), the Achilles functional index, the size of the macroscopic defect and histology (inflammatory cells, fibroblasts, reticulin and fibrillar extracellular matrix); the direction and size of the differences are not summarized in this profile. In cultured tenocytes, the peptide alone did not change growth but counteracted the growth inhibition caused by the aldehyde 4-hydroxynonenal.

  • AnimalAnimal study· Rattus norvegicus

    Rat gastric and duodenal lesion models (restraint stress, cysteamine, ethanol): lesion counts and mucosal endothelium

    Sikiric P, Seiwerth S, Grabarevic Z et al.Life Sciences1994PMID 7904712 (opens PubMed in a new tab)Title on PubMedDOI 10.1016/0024-3205(94)00796-9 (opens the publisher record in a new tab)

    Filed under BPC-157

    Model
    Rat models of gastric and duodenal lesions (restraint stress, cysteamine, 96% ethanol)
    Exposure
    BPC-157 vs reference agents
    Comparator
    H2 receptor antagonists (famotidine, cimetidine), dopaminergic agents and gut peptides (including somatostatin, neuropeptide Y, secretin and cholecystokinin)

    In three rat models of gastric and duodenal lesions, mucosal lesions were counted after BPC-157 and after each of the reference agents, and Monastral blue labeling was used to examine the mucosal endothelium. The authors report differences between BPC-157 and the reference agents; their direction and size are not summarized in this profile. Early primary study in an animal model.

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