Research

Published findings, in context.

Each finding is shown with the evidence level at which it was observed. A result in an animal model or in cell culture is not a result in humans.

Topic

All topics Tissue damage models Extracellular matrix Cell signaling Cerebral ischemia models Dermal fibroblasts

Evidence level

All levels In vitro Animal Human, observational Human, controlled Review

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All types In vitro study Animal study Observational (human)Controlled (human)Systematic review Narrative review Case report

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1 publication

Compounds filed under Extracellular matrix · Systematic review

ReviewSystematic review
Systematic review of 20 studies (18 preclinical, 2 randomized controlled trials) of GHK-Cu as a standalone intervention
“The Regenerative Potential of GHK-Cu in Aesthetic Medicine.”
Mokhtar J, Mohamed B, Haddad J, et al.Aesthetic Surgery Journal2026PMID 42619529 (opens PubMed in a new tab)DOI 10.1093/asj/sjag169 (opens the publisher record in a new tab)
Filed under GHK-Cu
Model
Systematic review (PubMed, Embase and Cochrane CENTRAL from inception through March 2026, following PRISMA) of studies of GHK-Cu as a standalone intervention
Twenty studies were included: 18 preclinical studies and 2 randomized controlled trials. The authors synthesize preclinical data on extracellular matrix synthesis (matrix proteins and glycosaminoglycans), metalloproteinase activity, cell proliferation, inflammatory markers and delivery systems. Their conclusions about the two human trials are not summarized in this profile, and not every included study is listed here.

For laboratory research use only. Not for human or veterinary use or consumption. Not for diagnostic use. Not evaluated by the U.S. FDA.