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Research

Published findings, in context.

Each finding is shown with the evidence level at which it was observed. A result in an animal model or in cell culture is not a result in humans.

Topic

All topicsTissue damage modelsExtracellular matrixCell signalingCerebral ischemia modelsDermal fibroblasts

Evidence level

All levelsIn vitroAnimalHuman, observationalHuman, controlledReview
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Study type

All typesIn vitro studyAnimal studyObservational (human)Controlled (human)Systematic reviewNarrative reviewCase report
Publication year

3 publications

Compounds filed under Cell signaling · Observational study in humans

  • Human, observationalObservational study in humans· Homo sapiens

    Uncontrolled pilot study in 2 adults: blood markers and vital signs at baseline and after exposure

    Lee E, Burgess K2025PMID 40131143 (opens PubMed in a new tab)Full record on PubMed

    Filed under BPC-157

    Model
    Uncontrolled pilot study at a private clinic in 2 adults (aged 58 and 68), both exposed to the peptide before the study; blood markers and vital signs recorded at baseline and after each exposure
    Sample size
    2
    Exposure
    BPC-157; single arm
    Comparator
    No control group

    Blood markers of heart, liver, kidney and thyroid function and vital signs were recorded at baseline and after each exposure, and the participants were asked about adverse events at each visit. With two participants, both previously exposed to the peptide, and no control group or blinding, the study cannot characterize safety; its result is not summarized in this profile.

  • Human, observationalObservational study in humans· Homo sapiens

    Single-arm open-label pilot study: symptom questionnaire in 12 women with interstitial cystitis

    “Effect of BPC-157 on Symptoms in Patients with Interstitial Cystitis: A Pilot Study.”

    Lee E, Walker C, Ayadi B2024PMID 39325560 (opens PubMed in a new tab)Full record on PubMed

    Filed under BPC-157

    Model
    Single-arm, open-label pilot study at a private clinic in 12 women aged 39–76 with moderate to severe interstitial cystitis
    Sample size
    12
    Exposure
    BPC-157 (compounded preparation); single arm
    Comparator
    No control group

    Symptoms were assessed with the Global Response Assessment questionnaire; the authors report responses from all 12 participants and no dropouts. Because this was an open-label pilot study without a control group or blinding and with a subjective outcome, its design does not allow any change to be attributed to the peptide. The self-rated result is not summarized in this profile.

  • Human, observationalObservational study in humans· Homo sapiens

    Retrospective chart review with a telephone survey: self-reported knee pain in 16 people, no control group

    Lee E, Padgett B2021PMID 34324435 (opens PubMed in a new tab)Full record on PubMed

    Filed under BPC-157

    Model
    Retrospective chart review (2019–2020) with a telephone survey at a private clinic; people with knee pain of various causes
    Sample size
    16
    Exposure
    BPC-157 as recorded in the charts; 4 of the 16 charts also record a second peptide
    Comparator
    No control group

    Of 17 people on record, 16 were reached by telephone 6 months to 1 year later and asked about their knee pain. There was no control group or blinding, the outcome was self-reported, and the abstract does not report imaging or validated function or quality-of-life instruments; the design carries a high risk of selection and recall bias and does not allow any change to be attributed to the peptide. The self-reported result is not summarized in this profile.

For laboratory research use only. Not for human or veterinary use or consumption. Not for diagnostic use. Not evaluated by the U.S. FDA.