Skip to content
Cart
Menu

Research

Published findings, in context.

Each finding is shown with the evidence level at which it was observed. A result in an animal model or in cell culture is not a result in humans.

Topic

All topicsTissue damage modelsExtracellular matrixCell signalingCerebral ischemia modelsDermal fibroblasts

Evidence level

All levelsIn vitroAnimalHuman, observationalHuman, controlledReview
More filters (study type, organism, year)

Study type

All typesIn vitro studyAnimal studyObservational (human)Controlled (human)Systematic reviewNarrative reviewCase report
Publication year

3 publications

Compounds filed under Cell signaling · Review

  • ReviewSystematic review

    Systematic review of 36 studies (35 preclinical, 1 in humans): mechanism, musculoskeletal endpoints, biotransformation and safety

    “Emerging Use of BPC-157 in Orthopaedic Sports Medicine: A Systematic Review.”

    Vasireddi N, Hahamyan H, Salata MJ et al.HSS Journal2025PMID 40756949 (opens PubMed in a new tab)DOI 10.1177/15563316251355551 (opens the publisher record in a new tab)

    Filed under BPC-157

    Model
    Systematic review (PubMed, Cochrane, Embase; through June 2024) of studies on mechanism, musculoskeletal outcomes, biotransformation and safety

    Of 544 records identified, 36 studies were included (35 preclinical and 1 in humans). The authors synthesize functional, structural and biomechanical measures from preclinical musculoskeletal models, together with GHR expression and inflammatory cytokine levels; the only study in humans was retrospective. No human safety data were found, and the evidence was graded as level IV and V.

  • ReviewNarrative review

    Critical narrative review of preclinical studies in rodent muscle and connective-tissue models

    Gwyer D, Wragg NM, Wilson SLCell and Tissue Research2019PMID 30915550 (opens PubMed in a new tab)Title on PubMedDOI 10.1007/s00441-019-03016-8 (opens the publisher record in a new tab)

    Filed under BPC-157

    Model
    Critical narrative review of preclinical studies in rodent muscle and connective-tissue models

    Critical review by an independent group (Loughborough University) of the preclinical literature in small rodent models of muscle and connective-tissue lesions. It notes that only a handful of research groups had studied the peptide in depth, that the effects reported in rodents had yet to be confirmed in humans and that the precise mechanisms still needed to be understood.

  • ReviewNarrative review

    Narrative review by the originating group: the BPC 157 fragment and its early rat lesion models

    Sikirić P, Petek M, Rucman R et al.Journal of Physiology, Paris1993PMID 8298609 (opens PubMed in a new tab)Title on PubMedDOI 10.1016/0928-4257(93)90038-u (opens the publisher record in a new tab)

    Filed under BPC-157

    Model
    Narrative review by the originating group of its own preclinical work

    Early overview by the originating group of its own work. It refers back to the group's isolation of a gastric juice peptide (BPC, Mr about 40,000), presents the fully characterized 15-amino-acid fragment BPC 157, which the authors consider essential for the activity they studied, and sets out their hypothesis that the stomach mediates responses to stress in other organs. It summarizes the group's lesion models in several organs and proposes the peptide as a possible endogenous mediator.

For laboratory research use only. Not for human or veterinary use or consumption. Not for diagnostic use. Not evaluated by the U.S. FDA.